The Joglekar Laboratory investigates the fundamental mechanisms that ensure accurate chromosome segregation during cell division. Using an interdisciplinary approach that integrates quantitative live-cell imaging, synthetic biology, biophysics, and computational modeling, the lab studies how the kinetochore and spindle assembly checkpoint coordinate the faithful inheritance of the genome. By developing innovative microscopy and molecular engineering tools, the lab seeks to uncover emergent properties of the mitotic machinery and understand how defects in these processes contribute to cancer and genomic instability.