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Publications

Full publication list in reverse chronological order. Research from the Joglekar Lab spanning kinetochore architecture, spindle assembly checkpoint signaling, and quantitative cell biology.

2026

How to Train Custom Cell Segmentation Models Using Cell-APP. ↗ New

2023

Signaling protein abundance modulates the strength of the spindle assembly checkpoint. ↗

The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex. ↗

2022

BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling. ↗

Kre28–Spc105 interaction is essential for Spc105 loading at the kinetochore. ↗

Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling. ↗

2019

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation. ↗

Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design. ↗

2018

Stu2 acts as a microtubule destabilizer in metaphase budding yeast spindles. ↗

2017

How Kinetochore Architecture Shapes the Mechanisms of Its Function. ↗

2015

The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling. ↗

Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds. ↗

2014

Assembling the protein architecture of the budding yeast kinetochore-microtubule attachment using FRET. ↗

2013

The Budding Yeast Point Centromere Associates with Two Cse4 Molecules during Mitosis. ↗

Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast. ↗

A sensitized emission-based calibration of FRET efficiency for probing the architecture of macromolecular machines. ↗

2012

Adaptor autoregulation promotes coordinated binding within clathrin coats. ↗

2010

Towards building a chromosome segregation machine. ↗

Mechanisms of force generation by end-on kinetochore-microtubule attachments. ↗

Vertebrate kinetochore protein architecture: Protein copy number. ↗

2009

Chromosome Segregation: Ndc80 Can Carry the Load. ↗

Condensin regulates the stiffness of vertebrate centromeres. ↗

In vivo protein architecture of the eukaryotic kinetochore with nanometer scale accuracy. ↗

Protein architecture of the human kinetochore-microtubule attachment site. ↗

2008

Chromosome Congression by Kinesin-5 Motor-Mediated Disassembly of Longer Kinetochore Microtubules. ↗

Counting Kinetochore Protein Numbers in Budding Yeast Using Genetically Encoded Fluorescent Proteins. ↗

Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis. ↗

Design features of a mitotic spindle: Balancing tension and compression at a single microtubule kinetochore interface in budding yeast. ↗

The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle. ↗

Molecular architecture of the kinetochore-microtubule attachment site is conserved between point and regional centromeres. ↗

2007

Nanochannels fabricated by high-intensity femtosecond laser pulses on dielectric surfaces.

2006

Molecular architecture of a kinetochore-microtubule attachment site. ↗

2004

Optics at critical intensity: applications to nanomorphing. ↗

2003

A Study of the Deterministic Character of Optical Damage by Femtosecond Laser Pulses and Applications to Nanomachining.

1999

Patterns of butterfly, bird and tree diversity in the Western Ghats.

Join the lab

We welcome undergrads, graduate students, and postdoctoral researchers who are creative, excited about science, and willing to learn to chase down important scientific questions.

Contact Ajit → ajitj@umich.edu